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This inspires the development of a supramolecular binary vesicle, which is composed of p -sulfonatocalix[4]arene and enzyme-cleavable myristoylcholine that undergoes enzyme-induced disassembly triggered by the cholinesterase, thereby enabling in vitro controlled release of the AD drug tacrine and demonstrating potential for targeted drug delivery (Guo et al., 2012)

abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice

This equates to a chain of carbon atoms that makes the molecule less soluble