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doi: 10.1038/s41588-021-00852-9

If you really want to get a sense of the full diversity of what endurance researchers are interested in these days, scanning these responses is a great start

Oncologists historically focus on tumor-directed issues and may under-recognize fatigue, whereas mental health professionals are trained to assess functional and mood aspects so a psychologist or psychiatrist might be more likely to initiate a conversation about fatigue severity and its emotional toll

Your body can synthesise it in the liver and kidneys, and you also get it from food (especially red meat and dairy) and supplements