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341 In a placebo-controlled study of 148 patients with diarrhea-predominant IBS (IBS-D), treatment with 1,500 mg mesalazine daily was associated with a significantly greater portion of responders (defined as patients having improvements in both abdominal pain and stool consistency for 2 months) at three months

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NAMPT and NRK1/2 are also localized to the nucleus and cytosol 48,83,84 , suggesting that only the final step of salvage is performed in the mitochondria, with a mitochondrial NMN transporter, Slc25a45, recently proposed 85