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Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (270, 271), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (209, 258, 259, 272, 273)

For some, statistically defined reference limits are used, whereas for others "true" cutoffs" based on a known relationship between the B12 biomarker and low body stores, functional impairment, or clinical signs of deficiency, are applied

These elevated iron levels are related in the progression of AD and cognitive decline

doi: 10.1111/nyas.12871