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The SKN-1/Nrf2 transcription factor can protect against oxidative stress and increase lifespan in C

Spermatozoa are vulnerable to oxidative attack due to both the lack of an adequate range of defensive enzymes resulting from the restricted distribution of cytoplasmic space and the susceptibility of sperm membrane lipids caused by significant amounts of polyunsaturated fatty acids

Although high levels of ROS can induce DNA damage, lipid peroxidation, and protein dysfunction, low to moderate levels have been shown to act as key signaling molecules that promote cancer cell proliferation, stemness maintenance, and migratory capacity [35]

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