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Using fatty acids to prolong the duration of the action of peptides and proteins was already a long established technique at Novo Nordisk and elsewhere and had been successfully applied to insulin (insulin detemir) (Knudsen, Lau)
Thus, abnormal estrogen metabolism, which results in increased E2 levels, may contribute to a higher occurrence of GD
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J Ind Microbiol Biotechnol 43:4553
