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For weekend warriors and recreational athletes alike, B12 injections may help bridge the gap between nutritional needs and actual intake, especially when training demands increase

While this does not guarantee human safety, it provides encouraging preliminary data

Hold the syringe like a dart, rest the needle against the skin at 90 (right angles) to the skin, push hard, bit harder, until suddenly the needle slides through

Methionine synthase catalyzes the transfer of a methyl group to S-adenosyl-homocysteine, generating S-adenosyl-methionine and hence methionine, while methylmalonyl-CoA mutase catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, which then enters the citric acid cycle (Figure 1) [4,5,6]