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Axonal injury in the CNS might raise the level of NfL in the CSF (Kawarabayashi et al., 2023), hence, from a pathophysiological perspective, the degree of axonal injury or degeneration was positively connected with the amount of NfL in CSF

Newer understandings of bioavailability might ultimately inform new trial designs that could show an even stronger effect, especially since plasma increases with low dose vitamin C treatments are both transient and diminished, especially in trials that don't establish rigorous, frequent dosing schedules

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O'Brien and Wong, 2011