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The catecholamine responsible for the 1 - and 2 AR-mediated stimulation of norepinephrine release did not rely on catecholamines secreted from the adrenals during the experiment

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Like at AMYRs, these features require the expansion of extracellular TM bundle of CTR through outward movements of TM1, ECL1/TM3, TM4/ECL2 and a small shift in the positioning of the mid-region of the peptide at the start of the N-terminal helix, relative to rAmy when bound to the CTR in the bypass conformation (Fig