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Nevertheless, vigilance is required, and biopsy or further diagnostic work-up should be considered if concerning features emerge

Most adverse effects reported in studies arise from supplementation doses far exceeding the dietary levels, highlighting the need for evidence-based guidelines to delineate thresholds for therapeutic versus harmful use

High expression of forkhead box D1 (FOXD1), which is closely related to a poor prognosis for patients with pancreatic cancer, promotes the upregulation of GLUT1 expression and glucose uptake in cancer cells by activating the transcription of solute carrier family 2 member 1 (SLC2A1) and the lncRNA HOXA11-AS, which aggravate the malignant behavior of cancer cells [27]