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However, the polyArg-tag/cation-exchange resins affinity pair shows low selectivity and the tag promotes aggregation of the protein due to chargecharge interactions (Hedhammar et al., 2005)

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Vasoprotective Effects of Resveratrol and SIRT1: Attenuation of Cigarette Smoke-Induced Oxidative Stress and Proinflammatory Phenotypic Alterations. American Journal of Physiology