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for instance, iron accumulation in microglia and astrocytes promotes the release of proinflammatory cytokines, exacerbating neuroinflammation and neuronal damage (Ryan et al., 2023

During DKD progression, gut microbiota-derived uremic toxins such as indoxyl sulfate (IS) and p-cresyl sulfate (pCS) accumulate in the body due to impaired renal clearance, further exacerbating oxidative stress and inflammatory injury in the kidneys, thus forming a vicious cycle (17)

Oxid Med Cell Longev 2023(1):9808100 Zhang G et al (2024) Silibinin induces both apoptosis and necroptosis with potential anti-tumor efficacy in lung cancer
