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Research consistently shows an inverse association between serum B12 and serum MMA levels, although researchers havent found specific cutoff points for determining B12 deficiency by way of serum B12 or MMA levels using cross-sectional data (Bailey, 2011, Bailey, 2013)
Irritation impairs the barrier function of already-thin skin, worsening photoaging over time

305 These results suggest that liver cells require a narrow window of SLC7A11 activity to maintain healthy liver function when exposed to a high-fat environment

That is, it may take actions primarily by inhibiting FTO to correct upstream metabolic dysregulation, and concomitantly by dampening the downstream inflammatory cascade and oxidative stress that directly fuel nociceptive and neuropathic signaling pathways
