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The mechanism operates through four pathways: competitive blockage of androgen receptors at the nuclear level, inhibition of androgen synthesis by blocking the enzyme responsible for converting androstenedione to testosterone, inhibition of 5-alpha reductase which reduces conversion of testosterone to its more potent form DHT, and an increase in sex hormone-binding globulin which reduces circulating free testosterone

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[DOI] [PubMed] [Google Scholar] 350.Tang NP

Combined Effects of Host Genetics and Diet on Human Gut Microbiota and Incident Disease in a Single Population Cohort