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Studies in keratinocyte cell lines suggest that activation of D2-like receptors drives keratinocyte inflammatory activity and dopamine can alter the activity of matrix metalloproteinases and wound healing, potentially affecting inflammation (Fig

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Therefore, diabetic metabolic dysregulation critically subverts pulmonary immune resilience by destabilizing surfactant integrity, amplifying infection susceptibility through combined biosynthetic, antimicrobial, and lipidome perturbations

This review delineates recent progress in understanding the structural characteristics, regulatory mechanisms, and disease relevance of glutamine-hydrolyzing synthetases in humans
