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Taken together, our data suggest that the acetyl-CoA buildup secondary to FASN deletion inhibits ATP citrate lyase and induces an accumulation of citrate/isocitrate
Clinical uses of MET inhibitors in chemoresistance As discussed above, a number of clinical trials have evaluated MET inhibitors as a monotherapy against other targeted therapies or standard of care chemotherapy regimens (see Table 1)
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Researchers believe that this phenomenon occurred because the public databases do not reflect the difference in the composition and content of TCM compounds
