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Description
Physical dependence on M365 develops through mu-opioid receptor downregulation and compensatory noradrenergic upregulation in the locus coeruleus, independent of whether DSM-5 criteria for HUD are met
however, supporting evidence remains limited and largely indirect
PLOS Biology 20(1): e3001494 1-36 Valoskova, K., Biebl, J., Roblek, M., Emtenani , S., Gyoergy, A., Misova, M., Ratheesh, A., Shkarina, K., Larsen, I.S.B, Vakhrushev, S.Y., Clausen, H., Siekhaus, D.E
However, the timing of your supplements still matters
