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differentiated 3T3-L1 adipocytes could be utilized as a cell-based system for mechanism-of-action and phenotypic characterization of NNMT inhibitors NNMT protein expression was found to be 37-fold higher in the adipocytes (day 9) vs pre-adipocyte (P 0.0001)

Accordingly, vitamin B12 has a significant role in promoting secretion of glucocorticoid insufficiency, which could be the cause of increased TSH caused by interference in thyroid hormone synthesis (Yasuda et al

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