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While clinical trials showed modest fat-loss effects, it does not produce the level of weight loss seen with modern GLP-1 medications like semaglutide or tirzepatide.

183190, Passeri, Giovanni, and Sandro Giannini

On average, individuals may lose: up to 2kg per week, depending on diet, activity level and consistency 1520% of body weight over time with regular use and lifestyle support Tirzepatide combined with B12 is designed to enhance fat loss while preserving lean muscle
