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In addition, artesunate decreased -SMA and cell cycle protein D1 levels and inhibited cell proliferation by targeting the PPAR-/TGF-1/Smad2/3 signaling pathway (Pan et al., 2021)

F., White, J

The mutations of IDH1 or IDH2 exhibit a neomorphic activity by converting glutaminederived KG to 2hydroxyglutarate (2HG), which competitively inhibits KGdependent histone and DNA demethylases (Dang et al , 2010

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