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Ascorbate has the ability, under in vitro conditions, to regenerate Vitamin E from its radical, tocopheryl form (see below)

Activation of the immune system and neuroinflammation The mRNA levels of proinflammatory cytokines and chemokines increase accompanied by OHP administration, and a strong correlation of this effect with the mechanical hypersensitivity development has been shown [81]

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[73] Superoxide dismutase is known to reverse fibrosis, possibly through de-differentiation of myofibroblasts back to fibroblasts