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For example, if the chemistry of our current FBXO22 ligands is an indication of potential biological functions, FBXO22 could be playing a role in oxidative stress sensing by recognizing protein aldehydes 32,33

Targeting ATF4-DDIT4/TXNIP induced mitochondrial dysfunction and ferroptosis: ISRIB as novel therapy for septic cardiomyopathy

c-MET receptor is also associated with GRB2-associated binding protein 1 (GAB1) phosphorylation and provides extra binding sites for other adaptor proteins

Brain Fog and Cognitive Dysfunction: Reducing gut-derived systemic inflammation directly lowers the amount of pro-inflammatory cytokines (like IL-6) crossing the blood-brain barrier, alleviating neuroinflammation and cognitive clouding