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This hypothesis was validated in a preclinical melanoma model, where blocking CD38 expression in T lymphocytes boosted NAD + levels, improving the effectiveness of adoptively transferred T cells (47)
Autologous hematopoietic stem cell transplantation (aHSCT) has been used since the 1990s to treat resistant relapse [34]
Bartelt A, Orlando P, Mele C, Ligresti A, Toedter K, Scheja L, et al
2019 May 22;11(5):1136
