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, Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance

There are only few case reports where vitamin B12 deficiency was solely attributed as the cause of pyrexia.[2,3,4] The exact cause of pyrexia in megaloblastic anemia is not known but a proposed mechanism is that megaloblastic anemia leads to hyperplasia and thus increased activity within the bone marrow leading to systemic pyrexia

Cameron HA, McKay RD

In particular, the harmonization led by the International Council for Harmonisation (ICH) through the E19 guideline , in alignment with foundational principles in ICH E3 clinical study reports , marks a major evolution in how sponsors can optimize safety data collection without compromising regulatory rigor or patient welfare