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Description
KEAP1 binds to NRF2 and enables the CUL3-mediated ubiquitination and proteasomal degradation of NRF2 (Kobayashi et al., 2004)
This can cause nonspecific presentations, including headache, nausea/vomiting, and confusion
Don't let the simple structure fool you - this molecule is your liver's most critical defense against cellular damage and toxin overload
Upon activation, NLRP3 assembles the inflammasome, activates caspase-1, and promotes the release of interleukin-1 (IL-1) and interleukin-18 (IL-18) [174,175]
