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Description
CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

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Hayes M, Ferruzzi MG

It has been speculated that cross-reactions with other drugs used to treat FXS patients, the long time of perpetuation in adult patients, irreversible changes during early brain development and difficulties in the outcome measures might have caused the failure, but the underlying reasons have remained unclear
