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Meanwhile, M2 macrophages-derived extracellular vesicle (EVs) could also convert activated M1 macrophages into M2 macrophages through in situ macrophage reprogramming and producing a distinct protein expression pattern characteristic of anti-inflammatory M2 macrophages

Youre still introducing a negative variable
Certo, M

Curcuminencapsulated nanoparticles can infiltrate cells in an in vitro model of HD, thereby decreasing their sensitivity to apoptosis [206]
