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A second isoenzyme (HSD3B1) is abundant in placenta, mammary gland and prostate

While preclinical data highlight its therapeutic potential (74), clinical progress has been slow due to unresolved delivery and diagnostic issues (144)

Time frame and selection criteria: The focus was primarily on articles published in the last two decades, with particular attention to comprehensive reviews, landmark studies, and significant clinical trials

By boosting NAD levels, these therapies can improve blood flow, support heart function, and enhance overall metabolic health, potentially reducing the risk of heart disease and promoting a healthier, more active lifestyle, when also combined with EDTA Chelation Therapy