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Whereas first-generation vaccines rely mainly on spike, there is strong evidence that adaptive immunity to nonspike antigens contributes to protection from infection and disease in natural infection
4 Adult growth hormone deficiency treatment with a combination of growth hormone and insulin-like growthfactor-1 resulting in elevated sustainable insulin-like growth factor binding protein 3 plasma levels. National Center for Biotechnology Information

In addition, despite the mechanistic appeal of antioxidant therapy, its translation remains constrained by major pharmacological barriers, including poor stability, limited bioavailability, suboptimal pharmacokinetics, and inadequate CNS delivery, especially for protein- and enzyme-based antioxidants
Dl-3-n-butylphthalide attenuates myocardial ischemia reperfusion injury by suppressing oxidative stress and regulating cardiac mitophagy via the PINK1/Parkin pathway in rats
