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Whereas first-generation vaccines rely mainly on spike, there is strong evidence that adaptive immunity to nonspike antigens contributes to protection from infection and disease in natural infection

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4 Adult growth hormone deficiency treatment with a combination of growth hormone and insulin-like growthfactor-1 resulting in elevated sustainable insulin-like growth factor binding protein 3 plasma levels. National Center for Biotechnology Information

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In addition, despite the mechanistic appeal of antioxidant therapy, its translation remains constrained by major pharmacological barriers, including poor stability, limited bioavailability, suboptimal pharmacokinetics, and inadequate CNS delivery, especially for protein- and enzyme-based antioxidants

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Dl-3-n-butylphthalide attenuates myocardial ischemia reperfusion injury by suppressing oxidative stress and regulating cardiac mitophagy via the PINK1/Parkin pathway in rats

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