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While the UPR initially aims to restore cellular equilibrium, chronic activation in cancer cells often promotes adaptation, survival, and therapy resistance (Sun et al., 2017)
[DOI] [PMC free article] [PubMed] [Google Scholar] 169.Gonzlez-Reyes R.E., Nava-Mesa M.O., Vargas-Snchez K., Ariza-Salamanca D., Mora-Muoz L
If the drug is given by a route that has a bioavailability less than 100%, then the dosing rate predicted by equation (9) must be modified
