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Loss of CXCR2 does not affect the loss of MBP and 2,3-Cyclic-nucleotide 3-phosphodiesterase (CNPase) expression within the first 2 weeks of cuprizone treatment, but by weeks 3 and 4 MBP and CNPase expression increases in CXCR2 / mice, suggesting that loss of CXCR2 protects against a delayed myelin protein loss [238]
