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Batiha et al., 2020

The activation of MAPK pathways can be induced or mediated by ROS [51]

As a model for physiological conditions the cancer cells were cultivated and treated with a 21% O 2 atmosphere, and as a model for hypoxic conditions the cancer cells were cultivated and treated with a 1% O 2 atmosphere

However, oxidative stress occurs when there is an imbalance between ROS production and cellular antioxidant activity