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Important safety considerations regarding antioxidant use include: High-dose supplements are not risk-free Excessive vitamin E intake has been associated with increased mortality risk in some meta-analyses and may increase prostate cancer risk in men, though evidence remains debated Drug interactions Antioxidants can interact with medications including anticoagulants (vitamin E, coenzyme Q10), insulin and sulfonylureas (alpha-lipoic acid), and some herbal products may affect liver enzyme metabolism Quality concerns Supplements not registered under the MHRA Traditional Herbal Registration scheme are not subject to the same rigorous testing as licensed medicines

10.1016/s0092-8674(00)81554-8 Cell 13 BrennaA.OlejniczakI.ChavanR.RippergerJ

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Per the rule, McCauley qualified for a one-year reduction to the otherwise asserted five-year period of ineligibility