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In the mPFC, DOIs inhibitory action was unaffected by MgCl (which prevents neurotransmitter release) but was blocked by several atypical neuroleptics, such as clozapine, ritanserin or risperidone, suggesting a direct, 5-HT 2A -mediated mechanism (Ashby et al., 1989

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Grnborg M, Kristiansen TZ, Stensballe A, Andersen JS, Ohara O, Mann M, et al
