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Selective PDE4 inhibitors include rolipram, roflumilast, and cilomilast with adverse side effects such as nausea, diarrhea, headache, and insomnia
Adiponectin provides protective metabolic signaling and declines with adiposity, lifting a brake on inflammation and insulin sensitivity that then affects estrogen and progesterone homeostasis
M.BalarP.OysterM.ZaleskiD.AdlerJ.et al (2021)