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NAD+ serves as an essential coenzyme for hundreds of enzymatic reactions, including those involved in energy production, DNA repair, and cellular signaling

[DOI] [PubMed] [Google Scholar] 4.Seiwerth S., Milavic M., Vukojevic J., Gojkovic S., Krezic I., Vuletic L.B., Pavlov K.H., Petrovic A., Sikiric S., Vranes H., et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 136.Wu G., Lupton J.R., Turner N.D., Fang Y.-Z., Yang S

This suggests extracellular metabolism happens before cellular uptake [18]
