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In preclinical cellular models, FOXO4-DRI has been reported to: Disrupt FOXO4p53 interaction and reduce nuclear co-localization in senescent cells Promote p53-dependent apoptosis preferentially in senescent, rather than proliferating, cells Decrease markers of cellular senescence (such as SA--gal positivity and selected SASP factors) in treated cultures In animal studies, administration of FOXO4-DRI has been associated with: Reduction of senescence markers in select tissues Improvements in certain functional readouts (such as aspects of physical performance or organ function) in aging or therapy-damaged models Modulation of inflammatory and tissue-remodeling profiles linked to senescent-cell burden These outcomes vary depending on model, dosing regimen, route and experimental design, and remain limited to exploratory preclinical work

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Nauck MA, Vardarli I, Deacon CF, Holst JJ, Meier JJ

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