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The results showed the time-dependent decomposition of these sugars to formic acid, glycolic acid, glyceric acid, tartronic acid, tartaric acid, acetic acid, and oxalic acid after direct exposure to plasma

The parasite genome demonstrates significant instability characterized by aneuploidy, copy number variations (CNVs), and single nucleotide polymorphisms that collectively facilitate rapid adaptation to therapeutic interventions ( Leishmania to develop resistance through various mechanisms including altered drug transport, target modification, and enhanced metabolic detoxification pathways ( Leishmania serves as an evolutionary advantage, allowing rapid selection of resistant populations under drug pressure