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Semi-saturation mutagenesis on the conformationally flexible H241 residue shows that only H241N and H241Q retained low activity, indicating that H241 is vital for the conformation required to bind PLP and tyrosine

This work sheds light on why some patients continue to lose vision despite current treatmentsand where new treatments may emerge

Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia

In patients with T2DM, persistently high blood glucose levels lead to an unusually high uptake of glucose by the liver
