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While this study demonstrates that CPT-1 is dispensable for macrophage polarization to M2 and highlights the importance of CoA availability, future research using genetic approaches should shed more light on the importance of FAO in M2 polarization ( Another distinctive feature of IL4-treated macrophages is the up-regulation of CD36 by PPAR, a signaling receptor and FA transporter that participates in macrophage alternative activation (73)

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Schizophrenia: While there are still a lot of unknowns about schizophrenia, researchers theorize that this psychological disorder is due to a lack of GAD1 in certain regions of the brain.[ref] This lack of GAD1 theoretically leads to an imbalance of too much glutamate (excitation) and too little GABA (inhibition)