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The motor performance of each rat was scored (04) before global cerebral ischemia and 24 hr after global cerebral ischemia/reperfusion, as follows: 0completely unable to walk on the beam

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showed that Sirt1 heterozygotes were more vulnerable to IRI and had an elevated level of the cyclin-dependent kinase (CDK) inhibitor, p21 [160]

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Tang JJ, Podratz JL, Lange M, Scrable HJ, Jang MH, Windebank AJ

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