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This explanation can also be a convictive evidence to support our result that selenium had advantage in preventing the incidence of Keshan disease
AMPK activation: MOTS-c activates AMP-activated protein kinase, the enzyme that functions as the cellular energy sensor

DNA methylation: DNA methylation is the addition of a methyl group to specific locations on a chromosome

Glutathione Neutralizes Free Radicals By reducing the amount of free radicals, glutathione prevents oxidative stress, which damages cells, proteins and DNA