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While promising for enhancing patient convenience, this method still requires further research to fully assess its effectiveness and safety ( The use of miRNAs to modulate the expression of the mutant A1AT gene and reduce the associated toxic effects has also been explored

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Genetic variations in VDBP/( CYP2R1 ) are known to influence 25(OH)VD blood levels in response to VD supplementation (13, 19, 23, 29, 30, 52)

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