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Critically, conditionally essential nutrients, when supplied exogenously, correct a clinically relevant outcome measure (Reference Grimble99,Reference Mischley100) In the context of clinical nutrition, Grimble in 1993 proposed five criteria to define conditionally essential nutrients in humans, whereby their deficiency results in either: failure to maintain growth or nitrogen balance, organ dysfunction, delayed recovery, metabolic or clinical abnormalities (Reference Grimble99)
In the clinical setting, population-based studies on vitamin E supplementation have been inconsistent at times and follow-up studies are needed
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The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo
