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CXCR4 antagonist AMD3100 modulates claudin expression and intestinal barrier function in experimental colitis

It can deacetylate protein substrates in various signal transduction pathways to regulate gene expression, cell apoptosis and senescence, participate in the process of neuroprotection, energy metabolism, inflammation and the oxidative stress response in living organisms, and plays an important role in toxic damage caused by toxicants and in the process of SIRT1 activator/inhibitor antagonized toxic damage

185,186,187 When mast cells in the gastrointestinal tract are deficient in antitumor-associated G protein-coupled receptor X2 (MRGPRX2), E
