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Description
Inhibitors Pieces of evidence for the transcriptional regulation of NRF2 highlighted that modifications of the NFE2L2 promoter region such as hypermethylation or single nucleotide polymorphisms, are responsible for a decreased NRF2 expression
[PMC free article: PMC2882727] [PubMed: 20237389] 532
Study shows that high glucose inhibits autophagy in human mesangial cells (HMCs), as indicated by a decreased LC3-II/LC3-I ratio and accumulation of the selective autophagy substrate p62
To investigate this hypothesis, we tested ATM for inhibition of PfTrx-2 activity in an insulin based assay
