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Markers of ROS, COX2, and ACSL4 are highly expressed at tissue, mRNA, and protein levels [263,264,265], while superoxide dismutase (SOD), an enzyme that inhibits ROS production, is downregulated [265]
Furthermore, patients with depression exhibit mitochondrial defects and dysfunction, which is the major source of ROS and site of apoptotic and necrotic processes [59]
and T lymphocyte activation is mediated by the secretion of immunologically active exosomes
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