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Several receptor antagonists, including YIL781, TAK-779, and AMD3100, were used to parse the involvement of specific receptor pathways, particularly the CXCR4 receptor, in mediating the observed effects [2]
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While disc degeneration exhibited significant effects on cervical spinal flexibility in all three primary motion planes, age had no significant effect in lateral bending but showed higher correlation coefficients with the cervical range of motion in flexion/extension and axial rotation compared to disc degeneration
