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AGEs are final, permanent products of glycation that can modify the physicochemical properties of proteins, increase their resistance to proteolysis, and interact with RAGE receptors, causing oxidative stress and an inflammatory response 57

In September 2021, the European Parliament passed a resolution with 99% support to phase out animal testing across member countries, focusing on plans and actions to accelerate the transition to innovation without using animals in research, regulatory testing, and education (213)

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