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Importantly, mutant SOD1 has been demonstrated to decrease the expression of antioxidant transcription factor NRF2 and its dependent target genes in an established NSC134 cellular model for SOD1-associated ALS (Kirby et al., 2005)
Invest Cell Pathol 2(3):195216 Fuchs CD, Trauner M (2022) Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology

Additional funding was provided by the National Science and Technology Major Project [no

Andersson & Arner, 2004)
